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holiday Inn Rome - Aurelia,Via Aurelia Km, 8400 00165, Rome, Italy About City Rome is the capital city of Italy and Lazio region with 2,872,800 residents in 1,285 km2. It is the fourth most populous city in the European Union by population within city limits. Rome is located in central western Italian peninsulas. Rome has acquired the status of a global city. In 2016, Rome has been ranked as the 14th most visited cities in the world and 3rd most visited cities in Europe. It is a city that is proud of its ancient glorious heritage, a city that once expanded its empire throughout Europe, Africa and Asia. The city of Rome includes tourist places such as Colosseum, Pantheon, Spanish Steps, the Forum, Trevi Fountain, and the catacombs any of the buildings have arches, domes and vaults. Colosseum is one of the famous architecture symbols in Rome which is capable of housing 60,000 spectators and it is the largest amphitheater ever built in the Roman empire and it was used for gladia
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Poster Presentation - Influence of NECC (Nutrition and Exercise Center for Cancer Patients) on survival and body composition in Gastrointestinal Cancer Patients

Abstract BACKGROUND : Gastrointestinal cancer patients are particularly predisposed to develop cancer cachexia. Cachectic patients are characterized by loss of adipose tissue as well as skeletal muscle wasting which has a tremendous impact on quality of life and survival (1, 4). In terms of improvement for this multifactorial syndrome, Klinikum rechts der Isar (MRI) in Munich, Germany has founded NECC, a treatment concept including nutrition intervention and an individual training program. METHODS : In this study we focused on patients with pancreatic (n =15) and upper gastrointestinal cancer (n = 21). Body composition using CT images was analyzed initially, 4 weeks, 3 months and 6 months after initial visit of NECC (Image 1). To underline the outcome, NECC patients were matched to adequate partners who correspond in age, gender, diagnosis with TNM classification and type of surgery. The control group does not receive any further support concerning nutrition and physical exercise
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Poster Presentation - Anesthetic management of a patient with Cancer and Hyperhomocysteinemia

Abstract Case : A 57-year-old female with a history of uterine and breast cancer s/p chemoradiation presented for cervical LEEP/cone biopsy/D&C. Her medical history was complicated by elevated LFTs with recent hyperhomocysteinemia (> 50micromol/l, normal 4-15). She was seen by a hematologist prior to surgery, and it was concluded that elevated homocysteine levels were due to cancer therapy and alcohol consumption. The procedure was performed under monitored sedation, with 2mg of Midazolam, 50mcg of Fentanyl, and a bolus of 70mg of Propofol followed by a steady infusion of 150mcg/kg/min.  Discussion : Causes of hyperhomocysteinemia include genetic predisposition, acquired deficiencies (folate, B6, B12), malignancies, and renal disease. Elevated homocysteine levels result in thromboembolic complications by causing endothelial dysfunction, increasing procoagulant activity, and decreasing the antithrombotic effect. Challenges of patients with hyperhomocysteinemia under
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Poster Presentation - The Immunogradient of CD8+ cell density in the tumour-stroma interface zone predicts overall survival of patients with hormone receptor-positive invasive ductal breast carcinoma

Abstract Statement of the Problem: Tumour-infiltrating lymphocytes (TIL) are associated with better prognosis in triple-negative and HER2-positive breast cancer (1, 2), and TIL assessment by digital image analysis (DIA) has been successfully implemented in colorectal and other cancers (3). However, results in hormone receptor-positive breast cancer (HRBC) based on manual scoring remain contradictory (2). Here we used an automated DIA method to extract the prognostic value of novel Immunogradient indicators in CD8+ cell density profiles in HRBC. Methodology & Theoretical Orientation: Surgically excised HRBC samples from 102 patients were immunohistochemically stained for CD8, digitized and analyzed by the HALO™ platform. The DIA data were subsampled by a hexagonal grid and explicit rules were then used to extract the tumor-stroma interface zone (IZ) and compute novel Immunogradient indicators from TIL density profiles across the IZ. The prognostic value was evaluated by surviva
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Poster Presentation - Prognostic value of CD8 Immunogradient indicators in tumour-stroma interface zone of colorectal cancer

Abstract Statement of the Problem: The immune response within the tumour microenvironment assessment methods were proposed to predict patient survival and therapy outcomes in colorectal (CRC) and other cancers; nevertheless, automated operator-independent approaches are lacking. We present a new image analysis method to automatically extract Immunogradient indicators and their prognostic value in CRC patients. Methodology & Theoretical Orientation: Surgically excised CRC samples from 101 patients were stained for CD8, scanned, and analyzed by Indica labs HALOTM software. The image analysis data was then subsampled by a hexagonal grid which was used to extract and rank the tumour interface zone (IZ) according to distance to the tumour edge. Lastly, a set of novel Immunogradient indicators representing CD8 cell density profiles across the IZ were computed. The prognostic value of the indicators was tested by univariate and multiple survival statistics. Findings: The Immunogradie
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Poster Presentation - Reactive carbonyl compounds of protein in patients’ blood after surgical treatment of breast cancer

Abstract Introduction . The problem of breast cancer (BC) is one of the important and complicated in oncology. In this aspect, there is a significant amount of interest in the study of oxidative processes, since their disorders can act as one of the pathogenetic factors of carcinogenesis. Aim of the study . To study the Reactive carbonyl compounds of proteins (RCCs) in plasma and in erythrocytes of blood of the BC patients after surgical treatment. Materials and methods . The blood of 20 women with BC was examined, which have I-IIIa stages after surgical treatment in the volume of radical resection or radical mastectomy performed at the first stage of treatment. The control group consisted of practically healthy women (n = 15). The level RCCs in erythrocytes and in blood plasma was determined by the method of Levine R.L et al. (1990). Results of the study . In erythrocytes of BC patients with I stage, there was a slight decrease in the percentage of RCCs. At the same
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Poster Presentation - The Notch ligand DLL1 exerts pro-carcinogenic effects in human breast cancer luminal A MCF-7 cells

Abstract  Background: Breast cancer (BC) is the most common cancer in women and has a high rate of relapse and death. The Notch signaling pathway plays an important role in normal breast development and homeostasis. Dysregulation of Notch receptors and its ligands Jagged1, Jagged2, and DLL4 has been detected in BC and implicated in tumor development, progression, drug resistance, and recurrence. The Notch ligand DLL1 has emerged as a player in BC as its expression is undetectable in normal breast tissues, but moderate to high in BC. In this study, we examined the role of DLL1 in BC luminal A MCF-7 cells. Methodology: DLL1 siRNA and recombinant DLL1 protein were used to evaluate the effects of DLL1 in MCF-7 cells. Gene expression was analyzed by qRT-PCR and immunoblotting. Cell growth and proliferation were assessed by trypan blue exclusion and MTT methods. Microscopy and scratch wound-healing assays were used to evaluate colony formation and cell migration. Findings: In M
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