Skip to main content

Poster Presentation - Influence of NECC (Nutrition and Exercise Center for Cancer Patients) on survival and body composition in Gastrointestinal Cancer Patients

Abstract

BACKGROUND: Gastrointestinal cancer patients are particularly predisposed to develop cancer cachexia. Cachectic patients are characterized by loss of adipose tissue as well as skeletal muscle wasting which has a tremendous impact on quality of life and survival (1, 4). In terms of improvement for this multifactorial syndrome, Klinikum rechts der Isar (MRI) in Munich, Germany has founded NECC, a treatment concept including nutrition intervention and an individual training program.
METHODS: In this study we focused on patients with pancreatic (n =15) and upper gastrointestinal cancer (n = 21). Body composition using CT images was analyzed initially, 4 weeks, 3 months and 6 months after initial visit of NECC (Image 1). To underline the outcome, NECC patients were matched to adequate partners who correspond in age, gender, diagnosis with TNM classification and type of surgery. The control group does not receive any further support concerning nutrition and physical exercise.

RESULTS: Our study demonstrates that NECC has impact on overall survival (Image 2). Skeletal muscle mass index (SMAI) was higher 4 weeks and 3 months after the initial visit in NECC patients compared to control group. Intramuscular adipose tissue index (IMATI) was higher after 6 months in NECC patients compared to controls.

CONCLUSION: The NECC program influences overall survival in patients with gastrointestinal cancer. This effect was significant in patients with pancreatic cancer but not in patients with upper GI cancer. Additionally, we observed effects of NECC on SMAI 4 weeks and 3 months after initial visit and on IMATI 6 months after the initial visit. The promising results should be further investigated in randomized studies.

Biography:
Nina Giulia Sautter graduated from Ludwig-Maximilians Universität in Summer 2018 in the field of Dentistry. She is passionately interested in the improvement of life quality of cancer patients. In 2016 she started her thesis about the importance of physical exercise and nutrition as a part of treatment in gastrointestinal cancer patients. The results of her research show a significant impact on the patient’s survival.

Comments

  1. LaraibJanuary 3, 2021 at 4:11 PM

    Hey There. I found your blog using This is a very well written article. I’ll be sure to bookmark it and come back to read more of your useful info. Thanks for the post. I’ll definitely return.
    cancer sign

    ReplyDelete
  2. drsundeepjainDecember 25, 2021 at 7:04 AM

    Thank you very much for sharing such a useful article. Will definitely saved and revisit your site best Esophagus Cancer Treatment in Jaipur

    ReplyDelete

Post a Comment

Popular posts from this blog

Conference Venue

holiday Inn Rome - Aurelia,Via Aurelia Km, 8400 00165, Rome, Italy About City Rome is the capital city of Italy and Lazio region with 2,872,800 residents in 1,285 km2. It is the fourth most populous city in the European Union by population within city limits. Rome is located in central western Italian peninsulas. Rome has acquired the status of a global city. In 2016, Rome has been ranked as the 14th most visited cities in the world and 3rd most visited cities in Europe. It is a city that is proud of its ancient glorious heritage, a city that once expanded its empire throughout Europe, Africa and Asia. The city of Rome includes tourist places such as Colosseum, Pantheon, Spanish Steps, the Forum, Trevi Fountain, and the catacombs any of the buildings have arches, domes and vaults. Colosseum is one of the famous architecture symbols in Rome which is capable of housing 60,000 spectators and it is the largest amphitheater ever built in the Roman empire and it was used for gladia...
2 comments
Read more

Poster Presentation - The Notch ligand DLL1 exerts pro-carcinogenic effects in human breast cancer luminal A MCF-7 cells

Abstract  Background: Breast cancer (BC) is the most common cancer in women and has a high rate of relapse and death. The Notch signaling pathway plays an important role in normal breast development and homeostasis. Dysregulation of Notch receptors and its ligands Jagged1, Jagged2, and DLL4 has been detected in BC and implicated in tumor development, progression, drug resistance, and recurrence. The Notch ligand DLL1 has emerged as a player in BC as its expression is undetectable in normal breast tissues, but moderate to high in BC. In this study, we examined the role of DLL1 in BC luminal A MCF-7 cells. Methodology: DLL1 siRNA and recombinant DLL1 protein were used to evaluate the effects of DLL1 in MCF-7 cells. Gene expression was analyzed by qRT-PCR and immunoblotting. Cell growth and proliferation were assessed by trypan blue exclusion and MTT methods. Microscopy and scratch wound-healing assays were used to evaluate colony formation and cell migration. Findings: ...
1 comment
Read more