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Feature Talk - The crucial role of CHI3L1 in Vasculogenic Mimicry formation of Cervical Cancer


Statement of the Problem: Over the past several decades, accumulating evidence has revealed that highly metastatic cancers are intimately associated with a vessel-like formation that is primarily derived from tumor cells, independent of endothelial cell-mediated angiogenesis. This alternative microvascular formation lacking endothelial cells is known as vasculogenic mimicry (VM). VM develops tumor vascular networks that associated tumor growth, metastasis, and short survival time of cancer patients. However, the knowledge of VM in the vascularization of cervical cancer are not fully understood yet. Chitinase-3-like-1 (CHI3L1) has been reported to plays a critical role in angiogenesis of cervical cancer. Here, we explored a pathological function of CHI3L1 in tumor cell-mediated vascularization. Methodology & Theoretical Orientation: The sixty-six tissue samples of cervical cancer were collected to determine CHI3L1 expression and VM formation using immunohistochemistry an…
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Feature Talk - Translational Potential of Non-coding RNAs in Oncology

For many years, the central dogma of molecular biology has been that RNA functions mainly as an informational intermediate between DNA sequence and its encoded protein. One of the great surprises of modern biology was the discovery that protein-coding genes represent less than 2% of the total genome sequence, and subsequently that almost 90% of the human genome is actively transcribed. Thus, human transcriptome was found to be more complex than a collection of protein-coding gene transcripts and their splice variants. Recent evidence has clearly shown that non-coding RNAs (ncRNAs) play major biological roles in cellular development, physiology and pathologies. ncRNAs are grouped into two major classes based on transcript size; small ncRNAs and long ncRNAs. Each of these classes can be further divided, whereas novel subclasses are still being discovered and characterized. In the last ten years, class of small ncRNAs called microRNAs was studied most intensively with more than…

Feature Talk - Identify and Characterize the Cancer Stemness Role of Maelstrom in Hepatocellular Carcinoma


Hepatocellular carcinoma (HCC) is the fourth most common type of cancer in Hong Kong SAR and ranks as the third leading mortality rate of cancer type worldwide. A wise strategy for better understanding the enrolled molecular mechanisms in HCC progression, which is needed to discover novel diagnostic markers and therapeutic targets. According to an analysis of our RNA sequence data of three paired HCC and non-tumor tissue samples, human maelstrom (MAEL) gene was chosen to study. Our preliminary data suggested that MAEL frequently upregulated in HCC patients, associated with tumor size, adjacent organ invasion, tumor recurrence, and worse overall survival rate. The previous study demonstrated that MAEL promoted HCC cells proliferation and metastasis as well as upregulating several stemness-related genes expression in mRNA level through AKT/GSK3β/Snail signaling pathways. However, the cancer stemness regulating ability and downstream targets of MAEL is still not well studied. …

Past Conference Report - Cancer Research

With great support from our Collaborators and Organizing Committee, PULSUS Conferences successfully completed the “Cancer 2018” which was held at Edinburgh, Scotland on March 26-27, 2018.
We would like to thank our Keynote Speakers for the conference - Hiroshi Kobayashi, Chiba University, Japan, William T. Beck, University of Illinois, USA, Shalini Gupta, King George Medical College, India, Antonio Gomez-Munoz, University Of The Basque Country, Spain, Barbara DeVivo, Westmont University, USA. for their support in making this event a great success.
We would like to extend our thanks to our collaborators “Sudanese Medical Research Association”, “Uganda Cancer Society” and “Pharmaceutical Society of Uganda” for their constant support. It wouldn’t have been possible without the support of our Media Partners who helped us in promoting this event. We thank our Media partners for their support in helping us reach a greater audience.
We also would like to thank all our Speakers, Poster Prese…